The Juventus striker will leave as his contract expires this month and Zanetti says negotiations are underway.
He told D-Sports Radio: "Dybala at Inter? We're talking about it, yes.
"He is a great player and he will certainly represent us at the World Cup. I admire Paulo and I wish him the best for his career.
"Inter has distinguished itself for having many South Americans, especially Argentines. It means that the players are worth it and also that the club has faith in the Argentines."